Side effects of JAK inhibitors identified so far include stomach upset, an increase in chest and skin infections and transaminaitis (an alteration in liver function identified by blood testing). Mild skin and upper respiratory tract infections have been reported in 25% of patients. Very few patients with alopecia areata elect to stop the medication as a result of side effects. Nevertheless patients receiving these medications require close medical supervision.
^ Martinez-Mir A, Zlotogorski A, Gordon D, Petukhova L, Mo J, Gilliam TC, Londono D, Haynes C, Ott J, Hordinsky M, Nanova K, Norris D, Price V, Duvic M, Christiano AM (February 2007). "Genomewide scan for linkage reveals evidence of several susceptibility loci for alopecia areata". American Journal of Human Genetics. 80 (2): 316–28. doi:10.1086/511442. PMC 1785354. PMID 17236136.
Alopecia areata is not contagious. It occurs more frequently in people who have affected family members, suggesting heredity may be a factor. Strong evidence of genetic association with increased risk for alopecia areata was found by studying families with two or more affected members. This study identified at least four regions in the genome that are likely to contain these genes. In addition, alopecia areata shares genetic risk factors with other autoimmune diseases, including rheumatoid arthritis, type 1 diabetes, and celiac disease. It may be the only manifestation of celiac disease.
Anti-androgens. Androgens include testosterone and other "male" hormones, which can accelerate hair loss in women. Some women who don't respond to minoxidil may benefit from the addition of the anti-androgen drug spironolactone (Aldactone) for treatment of androgenic alopecia. This is especially true for women with polycystic ovary syndrome (PCOS) because they tend to make excess androgens. Doctors will usually prescribe spironolactone together with an oral contraceptive for women of reproductive age. (A woman taking one of these drugs should not become pregnant because they can cause genital abnormalities in a male fetus.) Possible side effects include weight gain, loss of libido, depression, and fatigue.
Each follicle produces hair for 2 to 6 years and then takes a break for several months. While the hair follicle is in its rest phase, the hair falls out. There are around 100,000 follicles on the scalp, but because each follicle rests at a different time and others produce hairs, hair loss is usually unnoticeable. More noticeable hair loss occurs when there is a disruption to the growth and shedding cycle, or if the hair follicle is obliterated and replaced with scar tissue.
Laser devices: Brushes, combs, and other hand-held devices that emit laser light might stimulate hair growth. These devices might make hair look more youthful in some people. Because the FDA classifies these products as medical devices, the products do not undergo the rigorous testing that medicines undergo. The long-term effectiveness and safety for these devices are not known.
I’m so glad I came across this site. I’m 41 and started to lose my hair in Aug 2011. It started out as two bald spots in the back near the hairline. I went to a Dermatologist who started me on steroid injections, Topicort, and hair, skin and nails vitamins. After a few months, they didn’t seem to help. I went to my Internal Medicine md. He ordered all types of blood tests, $4,000 worth, which all but my Vitamin D came back normal. I started a Vitamin D supplement. He suggested I live my life and be happy. I then went to an Integrative Medicine md, who ran more blood tests that came back normal, urine tests that came back normal, and had me do a GI Repair Kit. I even tried going gluten free. I take a multivitamin, Omega 3, B Complex, Vitamin D 10,000 units, and hair, skin and nail Vitamins. I’ve cut out fast food and processed food. Drinking lots of water. Not exercising like I should. I began to gray in my twenties and have been dyeing my hair for years. The Dermatologist told me it didn’t cause the hair loss. I went months without dyeing my hair just to see if it would help. Nothing has helped or stopped my hair loss. I have now lost most of the hair in the back and on the left side over my ear leading to the front. A month a go I noticed a huge bald area on the right side in the front. I have been so depressed and self-conscious about my hair loss. I have been staying in the house and avoiding gatherings for fear of someone noticing. After spending lots of money and not getting any answers, I feel so helpless. I purchased a wig, but since my remaining hair is long and covers the bald areas, I haven’t started wearing it yet. It is a comfort knowing that I’m not the only one going through this. People don’t seem to understand. I know I’m not my hair, and my hair doesn’t make me, but it is a very traumatic thing to go through. I’ve decided to take my Internal Medicine md’s advice and to just live my life. I can’t continue to be depressed over something I can’t control. I wish everyone luck and I will continue to follow.
Because of its psychologic nature, the mainstays of treatment are counseling, behavior modification techniques, and hypnosis. Selective serotonin reuptake inhibitors and other medications for depression or obsessive-compulsive disorder may be used in some cases, although no medications are FDA-approved for treatment of trichotillomania.17 If a more moth-eaten appearance of hair loss is present and no evidence of hair-pulling behavior can be elicited, syphilis should be suspected.
For the first time in my life also, I have been experiencing a lot of scalp pain. I think it is because this time, it is not slow and diffuse like it was in my teenage years, at the onset of PCOS. Quitting the pill after 5 years of dependency meant a major hormonal shock to the system which provoked both a mix of both Telogen Effluvium (shock loss), and Androgenic Alopecia (the testosterone from the PCOS back in full form, killing hair follicles).
Men, oh yeah, different ball game. Just think how much money is spent on prostate research and medication versus female cancers!!!!! This IS a male society, but just smile, that makes you feel better. Do not let this get under your skin. KNOW who you are with or without hair, you are one fabulous person, loving and shining your light on this world. Step into that, claim it, own it. Whoever is unkind to you, just love them, bless them and wish them well. They have a bigger problem than you, trust me. And the WILL bump into it one day and not know what hit them.
Not surprisingly, treatments with 5 percent minoxidil work better than treatments with 2 percent minoxidil. A randomized clinical trial published in the American Journal of Clinical Dermatology in 2002 found that, in men with androgenetic alopecia, “5 percent topical minoxidil was clearly superior to 2 percent topical minoxidil and placebo in increasing hair growth.” The difference was actually pretty astounding — after 48 weeks, the men who used 5 percent minoxidil experienced 45 percent more hair growth than the men who used the 2 percent treatment.
I’m interested in what took place 4 months before the onset of your hair loss (and others with telogen effluvium). For me, it has always been either a baby born or a course of antibiotics. Oral birth control can also cause a sudden change in the gut flora–as can pretty much any medication. Staph infections are another connection I think should be pursued. Some women don’t know they’re colonized with Staph but they constantly have dry, cracked (mild or severe) sores in their noses.
Harklinikken (“hair clinic” in Danish) inspires great loyalty. Four out of five users come as referrals from satisfied customers, said Lars Skjoth, the company’s founder and chief scientist. The results are certainly compelling. After four months of daily application — that is, working the tea-colored tonic into the hair section by section, then letting it sit on the scalp for six hours — most users regain at least 30 percent of lost density, and some as much as 60 percent, according to company figures.