In 2010, a genome-wide association study was completed that identified 129 single nucleotide polymorphisms that were associated with alopecia areata. The genes that were identified include those involved in controlling the activation and proliferation of regulatory T cells, cytotoxic T lymphocyte-associated antigen 4, interleukin-2, interleukin-2 receptor A, and Eos (also known as Ikaros family zinc finger 4), as well as the human leukocyte antigen. The study also identified two genes, PRDX5 and STX17, that are expressed in the hair follicle.[18]
Diffuse female hair thinning and hair loss during premenopausal age is usually not heredity. It is usually caused by hormonal imbalances seeing in PCOS or thyroid disorder, nutritional deficiency (low iron), and stress. Women with PCOS produce high levels of androgens such as testosterones and DHEAS. The ratio of LH and FSH is also more than 2. Make sure you get your sex hormones check if you notice your hair thinning.

I am 30 and am trying Rogaine and spironolactone but only stopped the loss and I want to try Propecia. I know about the side effects for a male fetus, but I have chosen myself that I do not ever want to create a child out of my body. I will adopt or foster, but have intense lockeophobia. I even agreed to sign a legal document saying such, but my doctor would still not prescribe me propecia unless I had had a hysterectomy. He said it was for safety reasons, but as far as I understand it the only safety issue would be to such a fetus that will not exist. So I am confused about his reservations.


Lisa, don’t know if you are out there and reading this but I called my dermatology office today. I have worked with them since about 2003/2004 when I had severe cystic acne (it is about as bad as hair loss in dealing with it) and together the nurse and I were successful. I have hope, I got in to see her tomorrow and I’m taking all the meds/vitamins I am taking. Call Arizona Skin & Cancer Institute, they are in Chandler AZ right by Chandler Regional. I’ve been in tears all day because a clump came out. I thank God for my beautiful children who were there for me through the acne and my mom. You just listen to me talk about what I am going through. Getting through work was hard today. Anyway, Lisa call them and try to get in. I don’t know if I will have success but I’ve done a lot a research and I know what to ask. I did look up symptoms of protein deficiency – strange I had great hair in October 07 and my nails were really hard and now they are brittle and breaking and my hair is falling, I also went through a couple of weeks of this werid swelling of my arms, legs, feet, hands in April. And have been constipated, and my running isn’t giving me the usual firm legs, all signs of not enough protein. Maybe I’m grasping at straws but anyway…hope you are doing ok.
My ob-gyn gave me spirnolactone (?). I like the idea of finding an endocrinologist. I am changing insurance companies right now so as soon as I get sorted, I’ll be making an appointment for sure! I know there is something wrong with me, I lose hair by the handful daily. I’m hoping hair club will at least allow e to build some of my confidence back up while I try to find out what is really going on.

I’m 26 and started losing my hair (in the course of about a month) one year ago. I’ve seen three doctors about it. The General practitioner just pulled my hair and said it looks like my hairloss had already righted itself. Well, I didn’t believe her. So I went to a derm and he said he saw little regrowth hairs so it was just temporary hairloss and if, for some reason, I haven’t regrown my hair in to a noticable length in a year to come back to him for more bloodwork. (I had gotten my thyroid checked in my yearly physical and they said it was just slightly elevated . However, they told me this was not enough to put me on medication that they would check it again in one year) It has been one year and I think my hair is actually getting thinner. I’m just panicking. I’ve always had thick, straight as a board hair like another woman on this post had said, and now it is very thin, breaks easily and is ‘kinky’. I don’t understand why its kinky, why would my really long hairs that took years to grow now start to be damaged and kink when they fall out? I never got split ends, I never had short hairs fall out and when my hair did fall out in its normal pattern it would always fall out in one long, straight, thick strand. Does this mean I have a miniaturization of my follicles that has been going on for years? That maybe my hair strands are growing back thinner? I agree with another girl on this site that said she feels like there is no hope now. I was assured by my derm that my hair loss would not get worse. This helped me to cope a bit because instead of looking like someone with thick hair, I just had to look like someone with thin, wispy hair. I thought maybe I could deal with that, as long as I didn’t have to go bald. Well as much as this site has encouraged me in that ‘misery loves compay’ I now see that there are very few solutions and left untreated it can make us bald! I might also mention that I was never on birth control, and have no idea why I just suddenly started losing my hair. However, I have always had PMS and heavy periods. I guess I just want to know, is this for sure a problem with my hormones? Is it because my thyroid is slightly elevated? Should I even bother going to a doctor anymore? How can women as young as 18-30 be getting this problem? I guess I just am in that panic mode, where I really just want some reassurance that the odds of this getting better are good. I’ve past that one year mark of when I’m supposed to know if it was temporary or not and so now that sense of panic is renewed. Is this just going to keep getting worse? What do I do!? I hope some of you have some comments that could help me out. Thanks for listening to me rant.
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I also have been experiencing hair loss for the last 6 years and it is truly devastating. It is so hard to get up in the morning and go to work I feel so embarrassed, insecure and feel like every one around me is just staring at my head. I also just came across this website and I feel every one’s pain. For a woman, it is such a terrible thing to deal with. I will pray that we can all find the solution to this terrible situation. I live in Houston, TX and will be making an appointment with an endocrinologist soon.
I am on Arava and my hair has become extremely coarse, frizzy, and tight tight curls in the back. The sides of my hair are pure frizz and the top is straight, with frizz. It used to be smooth and so easy to manage. Now it takes so long and it looks awful. Anyone find the same thing and anything that helps? I have tried so very many hair products, so has my beautician. She says it is like I have 3 completely different textures on my head.
Before men or women invest in hair restoration, consultation and workup by a board-certified dermatologist experienced should be performed first to rule out other medical conditions that may trigger hair thinning and second to maximize medical therapy. Full medical therapy as prescribed and outlined by a board-certified dermatologist must continue in order to protect one's investment in hair transplant such as NeoGraft hair restoration.
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